Catalog Number: 1949
Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid
Biological Activity
Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo.
Technical Data
  • M.Wt:
    433.47
  • Formula:
    C22H21F2NO4S
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    121083-05-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
    Ford-Hutchinson et al.
    Can.J.Physiol.Pharmacol., 1989;67:989
  2. Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists.
    Girard et al.
    Prog.Clin.Biol.Res., 1989;301:585
  3. Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy.
    Beauchamp et al.
    J.Appl.Physiol., 2001;90:2279

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