L-670,596

Catalog # Availability Size / Price Qty
1949/10
L-670,596 | CAS No. 121083-05-4 | Prostanoid Receptor Antagonists
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Description: Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist

Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid

Purity: ≥98%

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Biological Activity

Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo.

Technical Data

M.Wt:
433.47
Formula:
C22H21F2NO4S
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
≥98%
Storage:
Store at RT
CAS No:
121083-05-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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