agonist; sensitizes PPARγ
by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα
heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα
and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo.
Cesario et al.
The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands.
International union of pharmacology LXIII. Retinoid X receptors.
Germain et al.
The "Phantom Effect" of the rexinoid LG100754: structural and functional insights.
Sato et al.
PLoS One, 2010;5:e15119