hh LG 100754 (CAS 180713-37-5): R&D Systems
Catalog Number: 3831
Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid
Biological Activity
Novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.
Technical Data
  • M.Wt:
    396.56
  • Formula:
    C26H36O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    180713-37-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo.
    Cesario et al.
    Mol.Endocrinol., 2001;15:1360
  2. The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands.
    Forman
    J.Biol.Chem., 2002;277:12503
  3. International union of pharmacology LXIII. Retinoid X receptors.
    Germain et al.
    Pharmacol.Rev., 2006;58:760
  4. The "Phantom Effect" of the rexinoid LG100754: structural and functional insights.
    Sato et al.
    PLoS One, 2010;5:e15119

Have you used LG 100754?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information