Pro-opiomelanocortin (POMC) derived peptide. Potentiates the steriodogenic action of corticotrophin on the adrenal cortex, possibly via the MC3
receptor. Potently stimulates lipolysis via activation of hormone-sensitive lipase (HSL).
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Evidence of a possible role fo Lys-γ3-MSH in the regulation of adipocyte function.
Harmer et al.
Lys-gamma3-MSH: a global regulator of hormone-sensitive lipase activity?
Bicknell et al.
The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal.
Harmer and Bicknell
Endocrine Res., 2004;30:629