Biological ActivityM 1145 is a potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.
(Modifications: Ala-27 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel GalR2-specific peptide agonist.
Runesson et al.
Citation for M 1145
The citations listed below are publications that use Tocris products. Selected citations for M 1145 include:
1 Citation: Showing 1 - 1
Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats.
Biochem Pharmacol 2018;156:241
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