(±)-McN 5652

Catalog # Availability Size / Price Qty
2148/10
2148/50
(±)-McN 5652 | CAS No. 96795-89-0 | 5-HT Transporter Inhibitors
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Description: Potent, orally active 5-HT uptake inhibitor; also inhibits noradrenalin and dopamine uptake in vitro
Alternative Names: McN 5652-Z

Chemical Name: (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline

Purity: ≥98%

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Biological Activity

Potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.

Technical Data

M.Wt:
295.44
Formula:
C19H21NS
Solubility:
Soluble to 50 mM in 1eq. HCl and to 75 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
96795-89-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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