Catalog Number: 2148
Alternate Names: McN 5652-Z
Chemical Name: (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline
Biological Activity
Potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
Technical Data
  • M.Wt:
    295.44
  • Formula:
    C19H21NS
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 75 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    96795-89-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. McN-5652: a highly potent inhibitor of serotonin uptake.
    Shank et al.
    J.Pharmacol.Exp.Ther., 1988;247:1032
  2. Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
    Maryanoff et al.
    J.Med.Chem., 1990;33:2793
  3. Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats.
    Smith et al.
    Eur.J.Pharmacol., 1991;196:85

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