Potent, high affinity serotonin re-uptake inhibitor; selective in vivo
. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro
values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo
following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
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All Tocris products are intended for laboratory research use only.
McN-5652: a highly potent inhibitor of serotonin uptake.
Shank et al.
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
Maryanoff et al.
Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats.
Smith et al.