Catalog Number: 0411
Chemical Name: 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
Biological Activity
Potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats.
    Buisson Defferier and Van den Buuse
    Eur.J.Pharmacol., 1992;223:133
  2. Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A receptor function in the rat in vivo.
    Gartside et al.
    Eur.J.Pharmacol., 1990;191:391
  3. Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice.
    Van der Hooff and Galvan
    Eur.J.Pharmacol., 1991;196:291

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