Mito-HE
Tocris Bioscience | Catalog # 7641
Key Product Details
Description
Wavelength
Product Description
Key information: Mito-HE is a red fluorescent mitochondrial superoxide indicator in live cells.Used for: live cell imaging, mitochondrial superoxide detection in Parkinson's and Alzheimer's disease in vitro models.
Application: confocal imaging, flow cytometry.
Properties and Photophysical Data: Selective for mitochondrial superoxides over other reactive oxygen and nitrogen species. Excitation and emission maxima (λ) are 510 nm and 580 nm, respectively; extinction coefficient = 117,000 M-1cm-1.
It is recommended to prepare stock solutions in DMSO.
Optical Data
| Emission Color | Red |
| λabs | 510 nm |
| λem | 580 nm |
| Extinction Coefficient (ε) | 11700 M-1cm-1 |
| Cell Permeable | Yes |
| Application | Confocal Imaging, Flow Cytometry |
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Product Specifications for Mito-HE
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Background References
References are publications that support the biological activity of the product.
- Chen Trilobatin protects against Aβ 25-35-induced hippocampal HT22 cells apoptosis through mediating ROS/p38/caspase 3-dependent pathway. Front.Pharmacol. 2020 PMID: 32508629
- Chung Parkin and PINK1 patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and α-synuclein accumulation. Stem Cell Rep. 2016 PMID: 27641647
- Robinson Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc.Natl.Acad.Sci.U.S.A. 2006 PMID: 17015830
- Mukhopadhyay Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat.Protoc. 2007 PMID: 17853886
- Mukhopadhyay Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem.Biophys.Res.Commun. 2007 PMID: 17475217
- Renaudin BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance. Cell Rep. 2021 PMID: 34348152
- Rhee Modeling secondary iron overload cardiomyopathy with human induced pluripotent stem cell-derived cardiomyocytes. Cell Rep. 2020 PMID: 32668256
Product Documents for Mito-HE
Certificate of Analysis
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Product Specific Notices for Mito-HE
For research use only
Citations for Mito-HE
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