Chemical Name: (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide
Biological ActivityBombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). Also binds GRPR (IC50 = 16 μM). Inhibits BA1-stimulated cytosolic Ca2+ and suppresses cell proliferation in a lung cancer model in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.
Moody et al.
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VersaClone cDNA Plasmids
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