Catalog Number: 5599
Chemical Name: (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide
Biological Activity
Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). Also binds GRPR (IC50 = 16 μM). Inhibits BA1-stimulated cytosolic Ca2+ and suppresses cell proliferation in a lung cancer model in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.
    Moody et al.
    Peptides, 2015;64:55
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