Bombesin receptor subtype 3 (BRS-3) antagonist (IC50
= 4.8 μ
M). Also binds GRPR (IC50
= 16 μ
M). Inhibits BA1
-stimulated cytosolic Ca2+
and suppresses cell proliferation in a lung cancer model in vitro
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All Tocris products are intended for laboratory research use only.
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.
Moody et al.