Mouse BACE-2 Ectodomain Antibody
Mouse BACE-2 Ectodomain Antibody Summary
Accession # Q9JL18
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
BACE-2 is an aspartic protease that shares sequence similarity with BACE-1, the major beta -secretase for generation of A beta peptide in neurons (1). However, BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in A beta peptide production (2‑4). The domain structure of mouse BACE-2 consists of a signal peptide (aa 1‑19), pro (aa 20‑62) and a mature chain (aa 63‑514) that consists of a transmembrane domain and a cytoplasmic tail. The C-terminal region (aa 463‑514) was replaced by a His tag in the recombinant mouse BACE-2 that also contained a His residue at the position of Tyr357. The purified recombinant mouse BACE-2 started at Ala63, the same residue shown at the N-terminus of the human active BACE-2 (2).
- Cai, H. et al. (2001) Nature Neurosci. 4:233.
- Hussain, I. et al. (2001) J. Biol. Chem. 276:23322.
- Ostermann, N. et al. (2006) J. Mol. Biol. 355:249.
- Sun, X. et al. (2005) FASEB J. 19:739.
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ExactaChIP Chromatin Immunoprecipitation Kits
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