Mouse CXCR4 PE-conjugated Antibody
Mouse CXCR4 PE-conjugated Antibody Summary
Met1-Ser359
Accession # P70658
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
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Detection of CXCR4 in Mouse Thymocytes by Flow Cytometry. Mouse thymocytes were stained with (A) Rat Anti-Mouse CXCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB21651P) or (B) Rat IgG2Bisotype control antibody (Catalog # IC013P) and Rat anti-Mouse CD8 alpha APC-conjugated Monoclonal Antibody (Catalog # FAB116A). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CXCR4
CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).
- Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
- Zagzag, D. et al. (2005) Cancer Res. 65:6178.
- Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
- Wang, L. et al. (2009) Oncology Reports 22:1333.
- Amara, S. et al. (2015) Cancer Biomark. 15:869.
Product Datasheets
Citations for Mouse CXCR4 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Homing of mRNA-Modified Endothelial Progenitor Cells to Inflamed Endothelium
Authors: D Canjuga, H Steinle, J Mayer, AK Uhde, G Klein, HP Wendel, C Schlensak, M Avci-Adali
Pharmaceutics, 2022;14(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Murine Myeloid Progenitors Attenuate Immune Dysfunction Induced by Hemorrhagic Shock
Authors: JT Cohen, M Danise, JT Machan, R Zhao, CT Lefort
Stem Cell Reports, 2021;16(2):324-336.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Integrins &alpha4&beta1 and &alphaV&beta3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease
Authors: A Filippi, A Constantin, N Alexandru, G Voicu, CA Constantin, D Rebleanu, M Fenyo, D Simionescu, A Simionescu, I Manduteanu, A Georgescu
Cell Transplant, 2020;29(0):9.6369E+14.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Integrins alpha4beta1 and alphaVbeta3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease
Authors: A Filippi, A Constantin, N Alexandru, G Voicu, CA Constantin, D Rebleanu, M Fenyo, D Simionescu, A Simionescu, I Manduteanu, A Georgescu
Cell Transplant, 2020;29(0):9636897209462.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK.
Authors: Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M
PLoS ONE, 2015;10(4):e0125340.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis.
Authors: Zheng, Jiao, Yang, Min, Shao, Jianghua, Miao, Yanju, Han, Jiahuai, Du, Jie
Mol Cancer, 2013;12(1):141.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
Authors: Tarrant, Teresa K, Billard, Matthew, Timoshchenko, Roman G, McGinnis, Marcus W, Serafin, D Stephe, Foreman, Oded, Esserman, Denise A, Chao, Nelson J, Lento, William, Lee, David M, Patel, Dhavalku, Siderovski, David P
J Leukoc Biol, 2013;94(6):1243-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.
Authors: Salvucci O, Jiang K, Gasperini P
Haematologica, 2012;97(6):818-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
Authors: Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD
Fertil. Steril., 2009;91(6):2687-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
Authors: Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV
J. Cell Biol., 2008;183(6):1145-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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