Mouse CXCR4 PE-conjugated Antibody

FAB21651P 6 Citations Datasheet / COA / SDS

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FAB21651P-025
FAB21651P-100

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Detection of CXCR4 in Mouse Thymocytes by Flow Cytometry.

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Citations (6)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse CXCR4 PE-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse CXCR4 transfectants. Does not stain irrelevant transfectants.

Source

Monoclonal Rat IgG_2B Clone # 247506

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Y3 rat myeloid cell line transfected with mouse CXCR4
Met1-Ser359
Accession # P70658

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Phycoerythrin

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry

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Detection of CXCR4 in Mouse Thymocytes by Flow Cytometry. Mouse thymocytes were stained with (A) Rat Anti-Mouse CXCR4 PE‑conjugated Monoclonal Antibody (Catalog # FAB21651P) or (B) Rat IgG_2B isotype control antibody (Catalog # IC013P) and Rat anti-Mouse CD8 alpha APC-conjugated Monoclonal Antibody (Catalog # FAB116A). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR4

CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and-2 viral entry into cells.

Entrez Gene IDs

7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)

Alternate Names

CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201ESDF-1 receptor; FB22; Fusin; HM89NPYRL; HSY3RR; LAP3; LCR1; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3RWHIM; NPYR; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Mouse CXCR4 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK.
Authors: Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M
PLoS ONE, 2015;10(4):e0125340.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow
Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis.
Authors: Zheng, Jiao, Yang, Min, Shao, Jianghua, Miao, Yanju, Han, Jiahuai, Du, Jie
Mol Cancer, 2013;12(1):141.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow
G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
Authors: Tarrant, Teresa K, Billard, Matthew, Timoshchenko, Roman G, McGinnis, Marcus W, Serafin, D Stephe, Foreman, Oded, Esserman, Denise A, Chao, Nelson J, Lento, William, Lee, David M, Patel, Dhavalku, Siderovski, David P
J Leukoc Biol, 2013;94(6):1243-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow
MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.
Authors: Salvucci O, Jiang K, Gasperini P
Haematologica, 2012;97(6):818-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow
CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
Authors: Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD
Fertil. Steril., 2009;91(6):2687-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow
The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
Authors: Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV
J. Cell Biol., 2008;183(6):1145-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow