Mouse Integrin  beta 3/CD61 PE-conjugated Antibody

FAB8557P has been discontinued. View all Integrin beta 3/CD61 products.
  
  • Species Reactivity
    Mouse
  • Specificity
    Detects mouse Integrin  beta 3/CD61 in direct ELISA.
  • Source
    Monoclonal Rat IgG1 Clone # 909114
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin alpha 2b and Integrin beta 3 linked heterodimer
    Leu32-Arg988 (Integrin alpha 2b) & Glu26-Asp717 (Integrin beta 3)
    Accession # NP_034705 (Integrin alpha 2b) & O54890 (Integrin beta 3)
  • Formulation
    Sodium Phosphate and Sodium Azide.
  • Label
    Phycoerythrin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of Integrin  beta 3/CD61 in P815 Mouse Cell Line by Flow Cytometry. P815 mouse mastocytoma cell line was stained with Rat Anti-Mouse Integrin  beta 3/CD61 PE‑conjugated Monoclonal Antibody (Catalog # FAB8557P, filled histogram) or isotype control antibody (Catalog # IC005P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin beta 3/CD61
Integrin beta 3 (ITGB3) is also known as platelet glycoprotein IIIa (GPIIIa) and CD61. Integrins are integral cell-surface proteins known to participate in both cell adhesion and cell-surface mediated signaling. They are composed of an alpha chain and a beta chain. ITGB3 is an integrin beta chain that forms a heterodimer with alpha-IIb or alpha-V chains. It is involved in platelet aggregation, and serves as an anchor for fibrinogen, allowing platelets to form aggregates or clots. A functional absense of ITGB3 leads to Glanzmann's thrombasthenia, a condition where platelets are activated, but fail to form an aggregate. Alternatively spliced transcripts encoding different proteins have been described, in human.
  • Entrez Gene IDs:
    3690 (Human); 16416 (Mouse); 29302 (Rat)
  • Alternate Names:
    CD61 antigen; CD61; GP3A; GP3Aplatelet glycoprotein IIIa; GPIIIA; GPIIIaintegrin beta-3; INGRB3; Integrin beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITG B3; ITGB3; Platelet membrane glycoprotein IIIa
Related Research Areas

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