|Detection of MS4A4B in NS0 Mouse Cell Line by Flow Cytometry. NS0 mouse myeloma cell line transfected with mouse MS4A4B and eGFP was stained with either (A) Rat Anti-Mouse MS4A4B PE‑conjugated Monoclonal Antibody (Catalog # FAB4504P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.|
Membrane Spanning 4 domain family, subfamily A4B (MS4A4B), also known as Chandra, is a member of the MS4A family of four-transmembrane proteins that includes CD20. It is expressed in immature CD4-CD8- T cells, NKT cells, CD4+ and CD8+ T cells, CD4+CD25+FoxP3+ Tregs and later in mature Th1 but not Th2 cells. MS4A4B is enriched in lipid rafts of activated T cells, and overexpression enhances Th1 cytokine expression, indicating a possible role in cell signaling.
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