Detects mouse TREML2/TLT-2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant
mouse (rm) TREM-1, -2, -2b, -3, -4, rmTREML1/TLT-1, rmTREML4/TLT-4, or
recombinant human (rh) NKp44 is observed.
Monoclonal Rat IgG2A Clone # 656906
Protein A or G purified from hybridoma culture supernatant
Chinese hamster ovary cell line CHO-derived recombinant mouse TREML2/TLT-2 His25-Ala270 Accession # Q2LA85
Supplied in a saline solution containing BSA and Sodium Azide.
Detection of TREML2/TLT‑2 in M1 Mouse Cell Line by Flow Cytometry.
M1 mouse myeloid leukemia cell line was stained with Rat Anti-Mouse TREML2/TLT‑2 APC‑conjugated Monoclonal Antibody (Catalog # FAB6707A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Receptor Expressed on Myeloid
cells-like 2), alsol known as TLT2, is a 42-45 kDa member of the TREM family of immune
modulatory proteins. In mouse, it is a 306 amino acid (aa) type I transmembrane
glycoprotein that contains a 246 aa extracellular domain (ECD). TREML2 is
expressed by CD5+ B-1 type B cells, marginal zone IgMhi IgDlo
B-2 type B cells, macrophages, microglia and neutrophils; it is absent from T
cells and monocytes (although human monocytes strongly express TREML2). While it is unclear what, or if, a protein
ligand for TREML2 exists, it is known to bind phosphatidylserine and initiate
efferocytosis (phagocytosis of apoptotic cells). TREML2 expression is promoted by TLR3
ligation, and once expressed and "activated", it appears to potentiate
downstream effects that arise from independent GPCR activation, such as
inflammatory mediator release and chemotaxis following chemokine binding to CXC
receptors. Over aa 25-270 (the ECD),
mouse TREML2 shares 78% and 52% aa sequence identity with rat and human TREML2,
respectively. With respect to mouse
TREML2 ECD similarity to mouse TREM2 and TREML1 ECD, there is less than 20% aa
sequence identity for each.
Triggering Receptor Expressed on Myeloid Cells-like 2
Entrez Gene IDs:
79865 (Human); 328833 (Mouse)
C6orf76; dJ238O23.1; FLJ13693; MGC149715; MGC149716; TLT2; TLT-2; TREML2; trem-like transcript 2 protein; triggering receptor expressed on myeloid cells-like 2; triggering receptor expressed on myeloid cells-like protein 2; UNQ6268/PRO20473
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