Mouse TREML2/TLT-2 APC-conjugated Antibody

  • Species Reactivity
  • Specificity
    Detects mouse TREML2/TLT-2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) TREM-1, -2, -2b, -3, -4, rmTREML1/TLT-1, rmTREML4/TLT-4, or recombinant human (rh) NKp44 is observed.
  • Source
    Monoclonal Rat IgG2A Clone # 656906
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Chinese hamster ovary cell line CHO-derived recombinant mouse TREML2/TLT-2
    Accession # Q2LA85
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of TREML2/TLT‑2 in M1 Mouse Cell Line by Flow Cytometry. M1 mouse myeloid leukemia cell line was stained with Rat Anti-Mouse TREML2/TLT‑2 APC‑conjugated Monoclonal Antibody (Catalog # FAB6707A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TREML2/TLT-2
TREML2 (Triggering Receptor Expressed on Myeloid cells-like 2), alsol known as TLT2, is a 42-45 kDa member of the TREM family of immune modulatory proteins. In mouse, it is a 306 amino acid (aa) type I transmembrane glycoprotein that contains a 246 aa extracellular domain (ECD). TREML2 is expressed by CD5+ B-1 type B cells, marginal zone IgMhi IgDlo B-2 type B cells, macrophages, microglia and neutrophils; it is absent from T cells and monocytes (although human monocytes strongly express TREML2). While it is unclear what, or if, a protein ligand for TREML2 exists, it is known to bind phosphatidylserine and initiate efferocytosis (phagocytosis of apoptotic cells). TREML2 expression is promoted by TLR3 ligation, and once expressed and "activated", it appears to potentiate downstream effects that arise from independent GPCR activation, such as inflammatory mediator release and chemotaxis following chemokine binding to CXC receptors. Over aa 25-270 (the ECD), mouse TREML2 shares 78% and 52% aa sequence identity with rat and human TREML2, respectively. With respect to mouse TREML2 ECD similarity to mouse TREM2 and TREML1 ECD, there is less than 20% aa sequence identity for each.
  • Long Name:
    Triggering Receptor Expressed on Myeloid Cells-like 2
  • Entrez Gene IDs:
    79865 (Human); 328833 (Mouse)
  • Alternate Names:
    C6orf76; dJ238O23.1; FLJ13693; MGC149715; MGC149716; TLT2; TLT-2; TREML2; trem-like transcript 2 protein; triggering receptor expressed on myeloid cells-like 2; triggering receptor expressed on myeloid cells-like protein 2; UNQ6268/PRO20473
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Rat IgG2A Allophycocyanin Isotype Control

Ctrl IC006A 7  
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Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 6
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 4
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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