Catalog Number: 5142
Chemical Name: 1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride
Biological Activity
Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A chemical tool box defines mitotic and interphase roles for Mps1 kinase.
    Lan and Cleveland
    J.Cell.Biol., 2010;190:21
  2. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
    Kwiatkowski et al.
    Nat.Chem.Biol., 2010;6:359
  3. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
    Miduturu et al.
    Chem.Biol., 2011;18:868
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