Mps1-IN-1 dihydrochloride

Key Product Details

Product Description

Mps1-IN-1 dihydrochloride is a selective monopolar spindle 1 (Mps1) kinase inhibitor (IC₅₀ = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.

Product Specifications for Mps1-IN-1 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Mps1-IN-1 dihydrochloride

The following data is based on the product molecular weight 608.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.22 mL	16.43 mL
5 mM	0.33 mL	1.64 mL	3.29 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Miduturu High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 2011 PMID: 21802008
• Lan and Cleveland A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 2010 PMID: 20624898
• Kwiatkowski Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 2010 PMID: 20383151

Product Documents for Mps1-IN-1 dihydrochloride