Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50
= 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.
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All Tocris products are intended for laboratory research use only.
A chemical tool box defines mitotic and interphase roles for Mps1 kinase.
Lan and Cleveland
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Kwiatkowski et al.
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
Miduturu et al.