Catalog Number: 5246
Chemical Name: 4-Ethyl-1,4-dihydro-5-[[(2-methoxyethyl)thio]carbonyl]-6-methyl-2-phenyl-3-pyridinecarboxylic acid ethyl ester
Biological Activity
TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin (Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
    Kaszas et al.
    J.Pharmacol.Exp.Ther., 2012;340:152
  2. Positive allosteric modulation of TRPV1 as a novel analgesic mechanism.
    Lebovitz et al.
    Mol.Pain, 2012;8
  3. Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).
    Roh et al.
    Bioorg.Med.Chem., 2008;16:9349

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