TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin
(Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice.
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Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
Kaszas et al.
Positive allosteric modulation of TRPV1 as a novel analgesic mechanism.
Lebovitz et al.
Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).
Roh et al.