Catalog Number: 2403
Chemical Name: 2-Phenoxy-6-(cyclohexylamino)purine hemioxalate
Biological Activity
High affinity adenosine A3 receptor antagonist (Ki = 47 nM) that displays > 200-fold selectivity versus A1, A2A and A2B receptors.
Technical Data
  • M.Wt:
    354.39
  • Formula:
    C17H19N5O.½C2H2O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1186195-57-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
    Perreira et al.
    J.Med.Chem., 2005;48:4910
  2. Adenosine receptors as therapeutic targets.
    Jacobson and Gao
    Nat.Rev.Drug Discov., 2006;5:247
  3. Progress in the pursuit of therapeutic adenosine receptor antagonists.
    Moro et al.
    Med.Res.Rev., 2006;26:131
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 3777 hemioxalate include:

1 Citations: Showing 1 - 1

  1. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
    Authors: Schneider Et al.
    Nature 2015;14:201

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