Catalog Number: 0384
Biological Activity
Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.
Technical Data
  • M.Wt:
    401.56
  • Formula:
    C19H35N3O4S
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    136632-32-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II.
    Francis et al.
    J.Biol.Chem., 1997;272:14961
  2. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.
    Sasaki et al.
    J.Enzyme Inhib., 1990;3:195

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