Very potent inhibitor of cathepsin L (Ki
= 0.6 nM) and the strongest inhibitor of cathepsin B (Ki
= 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro
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All Tocris products are intended for laboratory research use only.
Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II.
Francis et al.
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.
Sasaki et al.
J.Enzyme Inhib., 1990;3:195