Catalog Number: 1419
Alternate Names: NalBzOH
Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide
Biological Activity
Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.
Technical Data
  • M.Wt:
    445.52
  • Formula:
    C26H27N3O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    119630-94-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone
    Gistrak et al.
    J.Pharmacol.Exp.Ther., 1989;251:469
  2. Has the sun set on κ3-opioid receptors?
    Connor and Kitchen
    Br.J.Pharmacol, 2006;147:349
  3. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors.
    Olianas et al.
    Br.J.Pharmacol., 2006;147:360

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