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Naloxone benzoylhydrazone

Catalog #: 1419 Datasheet / COA / SDS

Discontinued Product

1419 has been discontinued.
View all Miscellaneous/Non-selective Opioid Compounds products.
Naloxone benzoylhydrazone | CAS No. 119630-94-3 | Miscellaneous/Non-selective Opioid Compounds
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Description: Full κ agonist, partial μ and δ agonist and antagonizes agonist-induced activation of NOP
Alternative Names: NalBzOH

Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide

Purity: ≥99%

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Biological Activity

Naloxone benzoylhydrazone is a mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.

Technical Data

M.Wt:
445.52
Formula:
C26H27N3O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
119630-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Has the sun set on κ3-opioid receptors?
    Connor and Kitchen
    Br.J.Pharmacol, 2006;147:349
  2. Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone
    Gistrak et al.
    J.Pharmacol.Exp.Ther., 1989;251:469
  3. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors.
    Olianas et al.
    Br.J.Pharmacol., 2006;147:360

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