Catalog Number: 3298
Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
Biological Activity
High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.
Technical Data
  • M.Wt:
    320.39
  • Formula:
    C18H20N6
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    178928-68-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells.
    Gazi et al.
    Eur.J.Pharmacol., 1999;372:R9
  2. I. NGD 94-1: Identification of a novel, high affinity antagonist at the human dopamine D4 receptor.
    Tallman et al.
    J.Pharmacol.Exp.Ther., 1997;282:1011
  3. II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1.
    Primus et al.
    J.Pharmacol.Exp.Ther., 1997;282:1020

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