Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
Biological ActivityHigh affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
I. NGD 94-1: Identification of a novel, high affinity antagonist at the human DA D4 receptor.
Tallman et al.
II. Localization and characterization of DA D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1.
Primus et al.
NGD 94-1 as an agonist at human recombinant DA D4.4 receptors expressed in HEK293 cells.
Gazi et al.
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