Chemical Name: Pyridine-3-carboxamide
Biological ActivityAnti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
Cimadamore et al.
Stem Cells., 2009;27:1772
A modified method of Ins producing cells' generation from bone marrow-derived mesenchymal stem cells.
Czubak et al.
J.Diabetes Res., 2014;2014:628591
Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake.
Suzuki et al.
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