Catalog Number: 4106
Chemical Name: Pyridine-3-carboxamide
Biological Activity
Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake.
    Suzuki et al.
    Life.Sci., 2010;86:676
  2. Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
    Cimadamore et al.
    Stem Cells., 2009;27:1772
  3. A modified method of insulin producing cells' generation from bone marrow-derived mesenchymal stem cells.
    Czubak et al.
    J.Diabetes Res., 2014;2014:628591
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