Nicotinamide
Chemical Name: Pyridine-3-carboxamide
Purity: ≥99%
Biological Activity
Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Organoid Models of Human and Mouse Ductal Pancreatic Cancer.
Boj SF, Hwang C, Baker LA et al.
Cell. -
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
Cimadamore et al.
Stem Cells., 2009;27:1772 -
A modified method of Ins producing cells' generation from bone marrow-derived mesenchymal stem cells.
Czubak et al.
J.Diabetes Res., 2014;2014:628591 -
Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake.
Suzuki et al.
Life.Sci., 2010;86:676 -
SnapShot: Growing Organoids from Stem Cells.
Sato et al.
Cell, 2015;161:1700 -
Establishment of gastrointestinal epithelial organoids
Mahe et al.
Curr.Protoc. Mouse Biol., 2014;3:217 -
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld et al.
Gastroenterology, 2015;148:126 -
Isolation and in vitro expansion of human colonic stem cells.
Jung et al.
Nat.Med., 2011;17:1227
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