Chemical Name: Pyridine-3-carboxamide
Biological ActivityNicotinamide is an anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration. Nicotinamide also acts as a SIRT1 inhibitor and promotes the expansion of hematopoietic progenitor cells
For more information about how Nicotinamide may be used, see our protocol:3D Culture of Lung Alveolar Cells
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Organoid Models of Human and Mouse Ductal Pancreatic Cancer.
Boj SF, Hwang C, Baker LA et al.
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
Cimadamore et al.
Stem Cells., 2009;27:1772
A modified method of Ins producing cells' generation from bone marrow-derived mesenchymal stem cells.
Czubak et al.
J.Diabetes Res., 2014;2014:628591
Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake.
Suzuki et al.
SnapShot: Growing Organoids from Stem Cells.
Sato et al.
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld et al.
Isolation and in vitro expansion of human colonic stem cells.
Jung et al.
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