Catalog Number: 3921
Chemical Name: N-(Piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Biological Activity
High affinity CB1 receptor antagonist (Ki = 4.1 nM). Exhibits significantly reduced lipophilicity compared to other CB1 antagonists.
Technical Data
  • M.Wt:
    459.37
  • Formula:
    C23H24Cl2N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    502486-89-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis, structure-activity relationship and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.
    Katoch-Rouse et al.
    J.Med.Chem., 2003;46:642
  2. Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity.
    Miller et al.
    Life Sci., 2007;81:63
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NIDA 41020 include:

1 Citations: Showing 1 - 1

  1. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci 2010;32:1

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