Catalog Number: 3013
Alternate Names: Melanotan I, MT-I, NDP-α-MSH
Biological Activity
Synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)

  • Solubility:
    Soluble to 0.60 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melanocortin receptors: perspectives for novel drugs.
    Eur.J.Pharmacol., 1999;375:295
  2. 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity.
    Sawyer et al.
    Proc.Natl.Acad.Sci.USA, 1980;77:5754

The citations listed below are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:

Showing Results 1 - 1 of 1

  1. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
    Authors: Schellekens Et al.
    J Biol Chem
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