Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50
= 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro
. Also AT4
receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
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All Tocris products are intended for laboratory research use only.
The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor.
Yamamoto et al.