Catalog # Availability Size / Price Qty
O-2050 | CAS No. 1883545-42-3 | Cannabinoid R1/CB1 Antagonists
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Description: Putative CB1 antagonist; displays mixed activity at CB receptors

Chemical Name: (6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran

Purity: ≥97%

Product Details
Citations (8)
Supplemental Products

Biological Activity

O-2050 is an originally defined as a high affinity cannabinoid CB1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
Store at -80°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from VCU-IPF

Background References

  1. Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist.
    Wiley et al.
    Eur.J.Pharmacol., 2011;651:96
  2. Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist.'
    Gardner and Mallet
    Eur.J.Pharmacol., 2006;530:103
  3. Agonists and silent antagonists in a series of cannabinoid sulfonamides.
    Martin et al.
    Symposium on the Cannabinoids, International Canna, 2002;

Product Datasheets

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Citations for O-2050

The citations listed below are publications that use Tocris products. Selected citations for O-2050 include:

8 Citations: Showing 1 - 8


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