O-2050

Tocris Bioscience | Catalog # 1655

Putative CB1 antagonist; displays mixed activity at CB receptors
Tocris Bioscience
Discontinued Product
1655 has been discontinued. View all Cannabinoid R1/CB1 Antagonists products.

Key Product Details

Description

Putative CB1 antagonist; displays mixed activity at CB receptors
View all Cannabinoid R1/CB1 Antagonists »

Product Description

O-2050 is an originally defined as a high affinity cannabinoid CB1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro.

Licensing Information

Sold under license from VCU-IPF

Product Specifications for O-2050

Molecular Weight

417.56

Formula

C23H31NO4S

Storage

Store at -80°C

Purity

≥97% (HPLC)

Chemical Name

(6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran

CAS Number

1883545-42-3

PubChem ID

16102146

InChI Key

DJTGGIYZQHHLGJ-RTBURBONSA-N

SMILES

OC1=CC(CC#CCCCNS(=O)(C)=O)=CC3=[C@@]1[C@@H]2CC(C)=CC[C@H]2[C@@](C)(C)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.76 100
Ethanol 41.76 100

Preparing Stock Solutions for O-2050

The following data is based on the product molecular weight 417.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.97 mL 23.95 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.20 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for O-2050

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for O-2050

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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