[Orn5]-URP
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Description: Urotensin-II (UT) receptor antagonist
Biological Activity
[Orn5]-URP is an urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.Technical Data
M.Wt:
1003.2
Formula:
C48H62N10O10S2
Sequence:
ACFWXYCV
(Modifications: X = Orn, Disulfide bridge between 2 - 7)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
782485-03-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Structure-activity relationships and structural conformation of a novel urotensin II-related peptide.
Chatenet et al.
Peptides, 2004;25:1819 -
[Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes.
Diallo et al.
Peptides, 2008;29:813
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