Biological Activity[Orn5]-URP is an urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.
(Modifications: X = Orn, Disulfide bridge between 2 - 7)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationships and structural conformation of a novel urotensin II-related peptide.
Chatenet et al.
[Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes.
Diallo et al.
Citation for [Orn5]-URP
The citations listed below are publications that use Tocris products. Selected citations for [Orn5]-URP include:
1 Citation: Showing 1 - 1
Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells.
Authors: Lee Et al.
PLoS One 2014;9:e90278
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