Endogenous glucagon-like peptide that modulates feeding and metabolism; secreted by intestinal L-cells. Increases cAMP production and inhibits gastric acid secretion in rat stomach. Also inhibits intestinal glucose absorption. Reduces fasting ghrelin levels following peripheral administration and reduces food intake and weight gain in rats following central or peripheral administration in vivo
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Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities.
Bataille et al.
A new role for enteric glucagon-37: acute stimulation of glucose absorption in rat small intestine.
Stumpel et al.
FEBS Lett., 1997;410:515
Peripheral oxyntomodulin reduces food intake and body weight gain in rats.
Dakin et al.
Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide.
Stanley et al.
Am.J.Physiol.Gastrointest.Liver Physiol., 2004;286:G693