Biological ActivityPotent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
(Modifications: Lys-6 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip.
Lee et al.
Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.
Choi et al.
Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis.
Bang et al.
Mol.Cell Proteomics, 2011;10:M110
Citations for P11
The citations listed below are publications that use Tocris products. Selected citations for P11 include:
2 Citations: Showing 1 - 2
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
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VersaClone cDNA Plasmids
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