Potent antagonist of the integrin αvβ3
-vitronectin interaction (IC50
= 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
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All Tocris products are intended for laboratory research use only.
High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip.
Lee et al.
Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.
Choi et al.
Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis.
Bang et al.
Mol.Cell Proteomics, 2011;10:M110