P11
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Description: Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
Biological Activity
Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.Technical Data
M.Wt:
720.78
Formula:
C30H48N12O9
Sequence:
HSDVHK
(Modifications: Lys-6 = C-terminal amide)
Solubility:
Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid
Storage:
Store at -20°C
CAS No:
848644-86-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip.
Lee et al.
J.Biomol.Screen., 2004;9:687 -
Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.
Choi et al.
Proteomics, 2010;10:72 -
Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis.
Bang et al.
Mol.Cell Proteomics, 2011;10:M110
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Citation for P11
The citations listed below are publications that use Tocris products. Selected citations for P11 include:
1 Citation: Showing 1 - 1
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Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Authors: Visavadiya
Cell Communication and Signaling 2016;14:32
FAQs
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