Catalog Number: 4744
Biological Activity
Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Lys-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip.
    Lee et al.
    J.Biomol.Screen., 2004;9:687
  2. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.
    Choi et al.
    Proteomics, 2010;10:72
  3. Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis.
    Bang et al.
    Mol.Cell Proteomics, 2011;10:M110
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