Biological ActivityP11 is a potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
(Modifications: Lys-6 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip.
Lee et al.
Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.
Choi et al.
Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis.
Bang et al.
Mol.Cell Proteomics, 2011;10:M110
Citations for P11
The citations listed below are publications that use Tocris products. Selected citations for P11 include:
2 Citations: Showing 1 - 2
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
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VersaClone cDNA Plasmids
Reviews for P11
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alpha v beta 3 peptide antagonist P11 10 µg/ml