PD 160170

Discontinued Product

2200 has been discontinued.
View all NPY Receptor Antagonists products.
PD 160170 | CAS No. 181468-88-2 | NPY Receptor Antagonists
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Description: Selective non-peptide NPY Y1 receptor antagonist

Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine

Purity: ≥98%

Product Details
Citations (2)

Biological Activity

Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists.
    Wright et al.
    Bioorg.Med.Chem.Lett., 1996;6:1809
  2. 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands.
    Wielgosz-Collin et al.
    J.Enz.Inhib.Med.Chem., 2002;17:449

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for PD 160170

The citations listed below are publications that use Tocris products. Selected citations for PD 160170 include:

2 Citations: Showing 1 - 2

  1. Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure.
    Authors: Zambrano Et al.
    Pharmacol Res Perspect  2015;3:e00111
  2. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Physiol Rep  2012;488:172


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