Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
Biological ActivityPotent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists.
Wright et al.
8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands.
Wielgosz-Collin et al.
Citations for PD 160170
The citations listed below are publications that use Tocris products. Selected citations for PD 160170 include:
2 Citations: Showing 1 - 2
Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure.
Authors: Zambrano Et al.
Pharmacol Res Perspect 2015;3:e00111
Deconstruction of a neural circuit for hunger.
Authors: Atasoy Et al.
Physiol Rep 2012;488:172
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