PD 160170

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2200/10
PD 160170 | CAS No. 181468-88-2 | NPY Receptor Antagonists
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Description: Selective non-peptide NPY Y1 receptor antagonist

Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine

Purity: ≥98%

Product Details
Citations (2)
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Reviews

Biological Activity

Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).

Technical Data

M.Wt:
371.41
Formula:
C18H17N3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
181468-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists.
    Wright et al.
    Bioorg.Med.Chem.Lett., 1996;6:1809
  2. 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands.
    Wielgosz-Collin et al.
    J.Enz.Inhib.Med.Chem., 2002;17:449

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Citations for PD 160170

The citations listed below are publications that use Tocris products. Selected citations for PD 160170 include:

2 Citations: Showing 1 - 2

  1. Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure.
    Authors: Zambrano Et al.
    Pharmacol Res Perspect  2015;3:e00111
  2. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Physiol Rep  2012;488:172

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