PD 404182

Catalog # Availability Size / Price Qty
PD 404182 | CAS No. 72596-74-8 | Synthase/Synthetase Inhibitors
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Description: High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor

Chemical Name: 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

Purity: ≥98%

Product Details

Biological Activity

High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.

Technical Data

Soluble to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase.
    Birck et al.
    J.Am.Chem.Soc., 2000;122:9334
  2. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.
    Ghebremariam et al.
    J.Pharmacol.Exp.Ther., 2013;348:69
  3. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide.
    Chamoun-Emanuelli et al.
    Antimicrob.Agents Chemother., 2014;58:687

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