PD 404182

Catalog # Availability Size / Price Qty
5124/10
Cat.No. 5124 - PD 404182 | C11H11N3S | CAS No. 72596-74-8
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Description: High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor

Chemical Name: 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

Purity: ≥98%

Product Details
Reviews

Biological Activity

High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.

Technical Data

M.Wt:
217.29
Formula:
C11H11N3S
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
72596-74-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.
    Ghebremariam et al.
    J.Pharmacol.Exp.Ther., 2013;348:69
  2. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide.
    Chamoun-Emanuelli et al.
    Antimicrob.Agents Chemother., 2014;58:687
  3. Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase.
    Birck et al.
    J.Am.Chem.Soc., 2000;122:9334

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