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PG 01

3943 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3943/10
3943/50
Other CFTR Compounds Small Molecule
1 Image
Description: CFTR potentiator; corrects F508del-CFTR conductance defect

Chemical Name: N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide

Purity: ≥98%

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Biological Activity

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Corrects gating defects of CFTR mutants such as ΔF508 (Ka = 0.3 μM), E193K and G970R (Kd values are 0.22 μM and 0.45 μM respectively). Increases ΔF508-CFTR Cl- currents in the presence of forskolin; displays no effect on Ca2+-activated Cl- current.

Technical Data

M.Wt:
439.55
Formula:
C28H29N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
853138-65-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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