Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
Biological ActivityPutative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines.
Mukherjee et al.
PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells.
Callister et al.
Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study.
Mukherjee et al.
Citation for PMX 464
The citations listed below are publications that use Tocris products. Selected citations for PMX 464 include:
1 Citation: Showing 1 - 1
Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death
Sci Rep 2017;7:43168
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