Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β
cells induces β
-cell apoptosis. Immunostimulant.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.
Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL).
Robbins et al.
Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12.
Rouas et al.
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
West et al.