Catalog Number: 2768
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Biological Activity
Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
Technical Data
  • M.Wt:
    341.79
  • Formula:
    C18H16ClN3O2
  • Solubility:
    Soluble to 50 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    196868-63-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.
    Anderson et al.
    J.Comb.Chem., 2006;8:784
  2. Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition.
    Sivakumar et al.
    , 2009;34:329
  3. Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
    Gable et al.
    Mol.Cancer, 2006;5:1079

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