PQ 401

Key Product Details

Product Description

PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC₅₀ value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.

Product Specifications for PQ 401

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PQ 401

The following data is based on the product molecular weight 341.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.85 mL	29.26 mL	58.52 mL
2.5 mM	1.17 mL	5.85 mL	11.70 mL
5 mM	0.59 mL	2.93 mL	5.85 mL
25 mM	0.12 mL	0.59 mL	1.17 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

• Gable Diarylureas are small-molecule inhibitors of Ins-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 2006 PMID: 16648580
• Anderson Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor. J.Comb.Chem. 2006 PMID: 16961415

Product Documents for PQ 401