Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50
value of 12 μ
M. Inhibits growth of MCF-7 breast cancer cells in vitro
and in vivo
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Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.
Anderson et al.
Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition.
Sivakumar et al.
Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
Gable et al.
The citations listed below are publications that use Tocris products. Selected citations for PQ 401 include:
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