Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Biological ActivityPQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor.
Anderson et al.
Diarylureas are small-molecule inhibitors of Ins-like growth factor I receptor signaling and breast cancer cell growth.
Gable et al.
Citations for PQ 401
The citations listed below are publications that use Tocris products. Selected citations for PQ 401 include:
5 Citations: Showing 1 - 5
Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
Ins-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.
Authors: Shen Et al.
Mol Cell Biol 2012;32:4116
Ins-like growth factor 1-mediated hyperthermia involves anterior hypothalamic Ins receptors.
Authors: Sanchez-Alavez Et al.
J Biol Chem 2011;286:14983
Activation of the Ins-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells.
Authors: Jameson Et al.
Mol Cancer Ther 2011;10:2124
Ins-like growth factor-I-stimulated Ins receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.
Authors: Radhakrishnan Et al.
J Biol Chem 2010;285:15682
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