PQ 401

Catalog # Availability Size / Price Qty
2768/10
2768/50
PQ 401 | CAS No. 196868-63-0 | Insulin and Insulin-like Receptor Inhibitors
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Description: IGF1R inhibitor

Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.

Technical Data

M.Wt:
341.79
Formula:
C18H16ClN3O2
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
196868-63-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor.
    Anderson et al.
    J.Comb.Chem., 2006;8:784
  2. Diarylureas are small-molecule inhibitors of Ins-like growth factor I receptor signaling and breast cancer cell growth.
    Gable et al.
    Mol.Cancer, 2006;5:1079

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