Recombinant Proteins

R&D Systems is the world’s premiere source of recombinant proteins. Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

Take advantage of R&D Systems portfolio of GMP Proteins for cell ex vivo applications, immune checkpoint proteins and enzymes, biotinylated proteins, and custom proteins to improve your immunotherapy research.   Avi-tag Biotinylated Recombinant Proteins
There are tens of thousands of additional proteins available beyond our website.   Watch this short video highlighting our CellXVivo™ kits developed for the consistent differentiation and expansion of T cells subtypes, dendritic cells, B cells, cytotoxic cells, and more.

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Quality Control

Our proteins work the first time and perform reproducibly for every manufactured lot.
Find out why.

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Bulk Recombinant Proteins

We have the ability to scale up protein production to meet your needs. Economical pricing means you don’t have to sacrifice quality to meet your budget.

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Custom Protein Development

Utilize our expertise in cloning, expression, purification, conjugation, and formulation to create the protein of your choice.

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GMP-grade Recombinant Proteins

R&D Systems offers the largest selection of GMP proteins. Learn more about our GMP-grade proteins and manufacturing processes.

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Non-Catalog Proteins

Not finding what you need? There are thousands of proteins not found on our website. Inquire today!

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Animal-Free Recombinant Proteins

We have dedicated facilities, equipment, and reagents to manufacture proteins with no exposure to animal byproducts.

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Bioassay Services

We have experience with over 900 established bioassays. Save setup and optimization time by partnering with our bioassay team.

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ProDots® Recombinant Proteins

Avoid aliquotting with our single use vials of lyophilized ProDots proteins that can be rolled directly into cell culture media.

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CellXVivo™ Immune Cell Differentiation Kits

Optimized cytokine formulations and protocols for the differentiation and expansion of dendritic cells, T cell subtypes, B cells, and regulatory T cells.

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Unique Model Organisms

From mammals and amphibians to bacteria and viruses. R&D Systems offers proteins that support research in a variety of important model organisms.

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Active Biotinylated Proteins

To ensure specificity, biotinylated proteins are tested in the same bioassay as the unconjugated form.


*Mullican, S. et al. (2017) Nat. Med 23:1150
**Mayers, JR and Vander Heiden, MG. (2013) Nat. Med b>19:816