PT 1

Catalog # Availability Size / Price Qty
4039/25
4039/5
AMPK Activators Small Molecule
1 Image
Description: AMPK activator

Chemical Name: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.

Technical Data

M.Wt:
497.91
Formula:
C23H16ClN3O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1.1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
331002-70-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.
    Jensen et al.
    Biochem.J., 2015;467:461
  2. Turning enzymes ON with small molecules.
    Zorn and Wells
    Nat.Chem.Biol., 2010;6:179
  3. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
    Pang et al.
    J.Biol.Chem., 2007;283:16051

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for PT 1

The citations listed below are publications that use Tocris products. Selected citations for PT 1 include:

2 Citations: Showing 1 - 2

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PT 1

There are currently no reviews for this product. Be the first to review PT 1 and earn rewards!

Have you used PT 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.