PT 1

  ( 1 citations )    
Product Datasheet
Catalog Number:4039
Chemical Name:2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid
Product Details
Citations (1)
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Biological Activity
AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.
Technical Data
  • M.Wt:
    497.91
  • Formula:
    C23H16ClN3O6S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1.1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    331002-70-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PT 1 include:

1 Citations: Showing 1 - 1

  1. The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy.
    Authors: Huang Et al.
    J Cardiovasc Pharmacol Ther  2016;21:70

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