PT 1 (CAS 331002-70-1): R&D Systems
Catalog Number: 4039
Chemical Name: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid
Biological Activity
AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.
Technical Data
  • M.Wt:
    497.91
  • Formula:
    C23H16ClN3O6S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1.1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    331002-70-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Turning enzymes ON with small molecules.
    Zorn and Wells
    Nat.Chem.Biol., 2010;6:179
  2. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
    Pang et al.
    J.Biol.Chem., 2007;283:16051
  3. PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.
    Jensen et al.
    Biochem.J., 2015;467:461

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