Chemical Name: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid
Biological ActivityAMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.
Jensen et al.
Turning enzymes ON with small molecules.
Zorn and Wells
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
Pang et al.
Citations for PT 1
The citations listed below are publications that use Tocris products. Selected citations for PT 1 include:
2 Citations: Showing 1 - 2
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.
Authors: Asiedu Et al.
PLoS One 2017;12:e0169882
The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy.
Authors: Huang Et al.
J Cardiovasc Pharmacol Ther 2016;21:70
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