Catalog Number: 4922
Biological Activity
Potent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.
Technical Data
  • M.Wt:
    3835.47
  • Formula:
    C155H249N51O47S8
  • Sequence:
    GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK

    (Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30)

    (Modifications: Lys-35 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    1396322-38-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of P2X3 receptors by spider toxins.
    Kabanova et al.
    Biochim.Biophys.Acta., 2012;1818:2868
  2. Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain.
    Grishin et al.
    Ann.Neurol., 2010;67:680

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Order Details

    4922 has been discontinued.

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