Catalog Number: 1080
Chemical Name: (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
Biological Activity

Full 5-HT1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.

Racemate and 7-Hydroxy Isomer also available.
Technical Data
  • M.Wt:
    328.29
  • Formula:
    C16H25NO.HBr
  • Solubility:
    Soluble to 75 mM in water and to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    78095-19-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
    Bjork et al.
    J.Med.Chem., 1989;32:779
  2. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase.
    Corrfield et al.
    Mol.Pharmacol., 1991;39:780
  3. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats.
    Yoshitake and Kehr
    Life Sci., 2004;74:2865
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:

3 Citations: Showing 1 - 3
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  1. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    Psychopharmacology (Berl) 2016;11:e0154932
  2. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
    Authors: Wierońska Et al.
    Oncoscience 2015;232:259
  3. Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram.
    Authors: Rossi Et al.
    Eur J Pharmacol 2008;583:103
Tocris Small Molecules
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8-Hydroxy-DPAT hydrobromide

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