serotonin receptor agonist; more active enantiomer. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo
. More active enantiomer of 8-Hydroxy-DPAT hydrobromide
(Cat. No. 0529). 7-Hydroxy-DPAT hydrobromide
(Cat. No. 0706) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
Bjork et al.
Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase.
Corrfield et al.
Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats.
Yoshitake and Kehr
Life Sci., 2004;74:2865
The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:
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