Very potent, high affinity H3
= 50.3 nM) that displays > 200-fold selectivity over H4
receptors. Inhibits H3
-mediated histamine synthesis and release in the CNS and stimulates H4
-mediated eosinophil shape change (EC50
= 66 nM). Part of the Histamine H3 Receptor Tocriset™
. (S)-(+)-α-Methylhistamine dihydrobromide
(Cat. No. 0572) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor.
Buckland et al.
Characterization of histamine-H3 receptors in guinea pig ileum with H3-selective ligands.
Hew et al.
Effects of histamine H3-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain.
Oishi et al.
Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
Menge et al.
J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
A third histamine receptor subtype - characterization, localization and functions of the H3-receptor.
Schwartz et al.
Agents Actions, 1990;30:13
The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-α-Methylhistamine dihydrobromide include:
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