Prototypical dopamine agonist (pKi
values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1
receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo
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Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.
Millan et al.
Low doses of apomorphine suppress operant motor performance in rats.
Liu et al.
Apomorphine protects against MPTP-induced neurotoxicity in mice.
Grunblatt et al.