Chemical Name: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride
Biological Activity(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apomorphine protects against MPTP-induced neurotoxicity in mice.
Grunblatt et al.
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.
Millan et al.
Low doses of apomor. suppress operant motor performance in rats.
Liu et al.
Citation for (R)-(-)-Apomorphine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Apomorphine hydrochloride include:
1 Citation: Showing 1 - 1
DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
Invest Ophthalmol Vis Sci 2018;59(6):2623
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