Catalog Number: 1545
Chemical Name: (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Biological Activity
L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
    Shi et al.
    Cell Stem Cell, 2008;3:568
  2. The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.
    Franckowiak et al.
    Eur.J.Pharmacol., 1985;114:223
  3. Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles.
    Ravens and Schopper
    Naunyn Schmiedebergs Arch.Pharmacol., 1990;341:232
  4. Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644.
    O'Neill and Bolger
    Brain Res.Bull., 1988;21:865
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