Inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β
-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.
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Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells.
Xu et al.
J.Lipid Res., 2003;44:415
Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes.
Agius et al.
Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor.
Rupp et al.
FASEB J., 1992;6:2349