Catalog Number: 0281
Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
Biological Activity
Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.

Available as part of the NMDA Receptor - Glycine Site Tocriset™. S-enantiomer also available.

Technical Data
  • M.Wt:
    116.12
  • Formula:
    C4H8N2O2
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    123931-04-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Other Product-Specific Information:
Background References
  1. Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in cat cultured cortical neurons.
    Kemp and Priestley
    Mol.Pharmacol., 1991;39:666
  2. Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
    Pullan et al.
    J.Neurochem., 1990;55:1346
  3. Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
    Pullan et al.
    Eur.J.Pharmacol., 1991;208:25
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:

1 Citations: Showing 1 - 1

  1. σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
    Authors: Paquette Et al.
    Elife 2008;19:111

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