Catalog Number: 2838
Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Biological Activity
α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
Technical Data
  • M.Wt:
    203.67
  • Formula:
    C9H13NO2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    61-76-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification.
    Ford et al.
    Br.J.Pharmacol., 1997;121:1127
  2. α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries.
    Morton et al.
    Br.J.Pharmacol., 2007;150:112
  3. Selectivity of agonists for cloned α1-adrenergic receptor subtypes.
    Minneman et al.
    Mol.Pharmacol., 1994;46:929
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus.
    Authors: Jin Et al.
    J Neurosci 2015;10:e0126956
  2. Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Authors: Lam Et al.
    PLoS One 2011;13:584

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