Catalog Number: 1349
Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Biological Activity
More active enantiomer of the PDE4 inhibitor rolipram (Cat. No. 0905); 2-10-fold more potent than the S-(+) enantiomer (Cat. No. 1350). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    275.35
  • Formula:
    C16H21NO3
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    85416-75-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
    Ohsawa et al.
    Jpn.J.Pharmacol., 1998;77:147
  2. Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
    Owens et al.
    Biochem.J., 1997;326:53
  3. Stereospecific binding of the antidepressant rolipram to brain protein structures.
    Schneider et al.
    Eur.J.Pharmacol., 1986;127:105
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Rolipram include:

1 Citations: Showing 1 - 1

  1. Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
    Authors: Boomkamp Et al.
    Br J Pharmacol 2014;171:2385

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