Recombinant Human BTN2A2/Butyrophilin 2A2 Fc Chimera (Catalog # 8918-BT) inhibits anti-CD3 antibody-induced IL-2 secretion in human T lymphocytes. The ED50 for this effect is typically 0.1-0.5 μg/mL.
Background: BTN2A2/Butyrophilin 2A2
Butyrophilin 2A2 (BTN2A2) is a widely expressed 65 kDa type I transmembrane glycoprotein that functions as a negative regulator of immune responses (1). Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Within the Ig-like domains, human Butyrophilin 2A2 shares 70% aa sequence identity with mouse and rat Butyrophilin 2A2. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Ig-like domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naïve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation (2, 3). Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells (2, 3). Its up-regulation in the hippocampus is associated with schizophrenia (4).
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Sinkus, M.L. et al. (2013) Brain Behav. Immun. 32:51.
Butyrophilin Subfamily 2 Member A2
Entrez Gene IDs:
10385 (Human); 238555 (Mouse); 306957 (Rat)
BTF2; BTF2BT2.2butyrophilin 2; BTN2; Butyrophilin 2; butyrophilin subfamily 2 member A2; butyrophilin, subfamily 2, member A2; FLJ41908
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