Recombinant Human Fc mu R/FAIM3 Protein, CF Summary
|Human Fc mu R/FAIM3|
Accession # O60667-1
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Reconstitution||Reconstitute at 200 μg/mL in PBS.|
|Shipping||The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
When human IgM is immobilized at 2 μg/mL, 100 μL/well, Recombinant Human Fc mu R/FAIM3 (Catalog # 9494-MU) binds with an ED50 of 0.4-2 μg/mL.
Background: Fc mu R/FAIM3
The human FAIM3 gene (also known as FCMR or TOSO), is a transmembrane sialoglycoprotein expressed mainly by lymphocytes. FAIM3 is a type I membrane protein with an intracellular C-terminal domain and an extracellular N-terminal domain (1). The extracellular domain has homology to the immunoglobulin variable region domains (1) and FAIM3 is identified as an Fc receptor for IgM (2, 3). The amino acid sequence of human FAIM3 is 58% and 55% identical to that of mouse and rat FAIM3, respectively. FAIM3 was shown to be over-expressed in chronic lymphocytic leukemia (CLL) (4) and associated with disease progression (5, 6). FAIM3 has also been linked to the homeostasis and activation of the innate immune system (7). Interestingly, there is growing evidence that neurodegenerative diseases are associated with the activation of the immune surveillance system. This system is responsible for controlling danger signals and responding accordingly to the magnitude and duration of the threat (8, 9).
- Song, Y. et al (2005) J. Biol. Chem. 280(10):9618.
- Shima H et al. (2010) Int. Immunol. 22:149.
- Kubagawa H et al. (2009) J. Exp. Med. 206:2779.
- Proto-Siqueira R et al. (2008) Blood, 112:394.
- Pallasch, C et al. (2008) Blood, 112:4213.
- Pallasch, C P et al (2009) Leukemia & lymphoma, 50:498.
- Sigruener, A et al (2007) Biochemical and biophysical research communications, 359:723.
- Richards R I et al (2016) Front. Neurosci. 10:193.
- Planells-Ferrer L et al (2016) J Neurochem. 139:11.
Citation for Recombinant Human Fc mu R/FAIM3 Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Diverse Functional Autoantibodies in Patients with COVID-19
Authors: EY Wang, T Mao, J Klein, Y Dai, JD Huck, F Liu, NS Zheng, T Zhou, B Israelow, P Wong, C Lucas, J Silva, JE Oh, E Song, ES Perotti, S Fischer, M Campbell, JB Fournier, AL Wyllie, CBF Vogels, IM Ott, CC Kalinich, ME Petrone, AE Watkins, CD Cruz, SF Farhadian, WL Schulz, ND Grubaugh, AI Ko, A Iwasaki, AM Ring
medRxiv : the preprint server for health sciences, 2020;0(0):.
Sample Types: Plasma
Applications: ELISA Capture
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