Recombinant Mouse FGF basic Protein, CF

(83 citations)   
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Rizzino, A. et al. (1988) Cancer Res. 48:4266; Thomas, K. et al. (1987) Methods Enzymol. 147:120. The ED50 for this effect is 0.3-1.8 ng/mL.
  • Source
    E. coli-derived Ala11-Ser154
  • Accession #
  • N-terminal Sequence
    Analysis
    Ala11
  • Predicted Molecular Mass
    16.2 kDa
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
3139-FB/CF
 
3139-FB
Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4, EDTA and DTT.
Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4, EDTA and DTT with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Mouse FGF basic (Catalog # 3139-FB/CF) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The ED50 for this effect is 0.3-1.8 ng/mL.
1 μg/lane of Recombinant Mouse FGF basic was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 18 kDa.
Background: FGF basic

FGF basic (FGF-2, HBGF-2) is one of at least 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation (1-3). Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. Storage pools within the cell or on cell surface heparan sulfate proteoglycans (HSPG) are likely. The predicted 17 kDa FGF basic isoform can be located in both the cytoplasm and the nucleus and is presumed to be the form secreted (4). Transcription from alternate start sites produces 21-24 kDa forms found only in the nucleus. High and low molecular weight human FGF basic targets the expression of different genes when expressed in NIH-3T3 cells (5). The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine and sheep FGF basic (6, 7). Autocrine, intracrine and paracrine actions of FGF basic have been identified. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysaccharides and lipids with lower affinity (3). Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis reminiscent of a variety of pathological conditions (1-3).

  • References:
    1. Coulier, F. et al. (1997) J. Mol. Evol. 44:43.
    2. Fernig, D. et al. (1994) Prog. Growth Factor Res. 5:353.
    3. Presta, M. et al. (2005) Cytokine. Growth Factor Rev. 16:159.
    4. Claus, P. et al. (2003) J. Biol. Chem. 278:479.
    5. Quarto, N. et al. (2005) Gene 356:49.
    6. Tsuneto, M. et al. (2005) Biochem. Biophys. Res. Comm. 335:1239.
    7. Hebert, J. M. et al. (1990) Dev. Biol. 138:454.
  • Long Name:
    Fibroblast Growth Factor basic
  • Entrez Gene IDs:
    2247 (Human); 14173 (Mouse); 281161 (Bovine); 403857 (Canine); 100033955 (Equine)
  • Alternate Names:
    basic fibroblast growth factor bFGF; Basic fibroblast growth factor; bFGF; FGF basic; FGF2; FGF-2; FGF2AS; FGFBprostatropin; fibroblast growth factor 2 (basic); GFG1; HBGF-2; HBGH-2; heparin-binding growth factor 2; NUDT6; Prostatropin
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

83 Citations: Showing 1 - 10
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Sample Type
  1. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na�ve ESCs
    Authors: Y Shan, Z Liang, Q Xing, T Zhang, B Wang, S Tian, W Huang, Y Zhang, J Yao, Y Zhu, K Huang, Y Liu, X Wang, Q Chen, J Zhang, B Shang, S Li, X Shi, B Liao, C Zhang, K Lai, X Zhong, X Shu, J Wang, H Yao, J Chen, D Pei, G Pan
    Nat Commun, 2017;8(1):672.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells
    Authors: ST Boyle, KA Gieniec, CE Gregor, JW Faulkner, SR McColl, M Kochetkova
    Mol. Cancer, 2017;16(1):19.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
    Authors: L Leiss, E Mutlu, A Øyan, T Yan, O Tsinkalovs, L Sleire, K Petersen, MA Rahman, M Johannesse, SS Mitra, HK Jacobsen, KM Talasila, H Miletic, I Jonassen, X Li, NH Brons, KH Kalland, J Wang, PØ Enger
    BMC Cancer, 2017;17(1):108.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Substance P accelerates wound healing in type 2 diabetic mice through endothelial progenitor cell mobilization and Yes-associated protein activation
    Authors: J Um, J Yu, KS Park
    Mol Med Rep, 2017;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  5. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways
    Authors: F Lacour, E Vezin, CF Bentzinger, MC Sincennes, L Giordani, A Ferry, R Mitchell, K Patel, MA Rudnicki, MC Chaboissie, AA Chassot, F Le Grand
    Cell Rep, 2017;18(10):2320-2330.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  6. DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of�Mesenchymal Stromal Cells
    Authors: CW Lee, WC Huang, HD Huang, YH Huang, JH Ho, MH Yang, VW Yang, OK Lee
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. FGF23/FGFR4-mediated left ventricular hypertrophy is reversible
    Authors: A Grabner, K Schramm, N Silswal, M Hendrix, C Yanucil, B Czaya, S Singh, M Wolf, S Hermann, J Stypmann, GS Di Marco, M Brand, MJ Wacker, C Faul
    Sci Rep, 2017;7(1):1993.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  8. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module
    Nat Commun, 2016;7(0):12277.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation
    Sci Rep, 2016;6(0):26562.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  10. Sequential Differentiation of Embryonic Stem Cells into Neural Epithelial-Like Stem Cells and Oligodendrocyte Progenitor Cells
    PLoS ONE, 2016;11(5):e0155227.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles
    Proc Natl Acad Sci USA, 2016;113(20):5552-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. Remission for Loss of Odontogenic Potential in a New Micromilieu In Vitro
    Authors: Y Zheng, J Cai, AP Hutchins, L Jia, P Liu, D Yang, S Chen, L Ge, D Pei, S Wei
    PLoS ONE, 2016;11(4):e0152893.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Myosin heavy chain is stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle
    Authors: J Hong, JS Park, H Lee, J Jeong, H Hyeon Yun, H Yun Kim, YG Ko, JH Lee
    Exp Mol Med, 2016;48(0):e225.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  14. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
    Authors: Eva Hedlund
    Sci Rep, 2016;6(0):26448.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus
    Authors: Joon W Shim
    Sci Rep, 2016;6(0):26794.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells
    Elife, 2016;5(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice
    Authors: M Rozo, L Li, CM Fan
    Nat. Med, 2016;22(8):889-96.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
    Nat Commun, 2016;7(0):13509.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
    PLoS ONE, 2016;11(10):e0164579.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis
    Authors: Cuiling Qi
    Sci Rep, 2016;6(0):27819.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  21. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease
    Sci Rep, 2016;6(0):37443.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.
    Authors: Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, Pratt T
    PLoS ONE, 2015;10(6):e0130147.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  23. Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells.
    Authors: Merkely B, Gara E, Lendvai Z, Skopal J, Leja T, Zhou W, Kosztin A, Varady G, Mioulane M, Bagyura Z, Nemeth T, Harding S, Foldes G
    Stem Cells Dev, 2015;24(7):869-78.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo injection
  24. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.
    Authors: Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders D, Chen J
    Mol Cell Biol, 2015;35(7):1299-313.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury.
    Authors: Chen, Long-Xia, Ma, Si-Min, Zhang, Peng, Fan, Zi-Chuan, Xiong, Man, Cheng, Guo-Qian, Yang, Yi, Qiu, Zi-Long, Zhou, Wen-Hao, Li, Jin
    PLoS ONE, 2015;10(3):e0115997.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury.
    Authors: Ma S, Chen L, Lin Y, Yan H, Lv J, Xiong M, Li J, Cheng G, Yang Y, Qiu Z, Zhou W
    PLoS ONE, 2015;10(4):e0123585.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Temporal expression of growth factors triggered by epiregulin regulates inflammation development.
    Authors: Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M
    J Immunol, 2015;194(3):1039-46.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells.
    Authors: Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E
    PLoS ONE, 2015;10(7):e0133746.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. Signal transducer and activator of transcription-3 maintains the stemness of radial glia at mid-neurogenesis.
    Authors: Hong S, Song M
    J Neurosci, 2015;35(3):1011-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. TGFbeta signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
    Authors: Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, Novitskiy S
    PLoS ONE, 2015;10(1):e0117908.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein.
    Authors: Zheng Y, Zou F, Wang J, Yin G, Le V, Fei Z, Liu J
    J Biol Chem, 2015;290(14):8975-86.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development.
    Authors: Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins T, Wang F, Feng G, Gotoh N, Zhang X
    J Cell Sci, 2014;127(0):571-82.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation: role of interferon-gamma.
    Authors: Hu S, Rotschafer J, Lokensgard J, Cheeran M
    PLoS ONE, 2014;9(8):e105219.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1.
    Authors: Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K
    Cancer Res, 2014;74(7):2026-37.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo injection
  35. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
    Authors: Chong J, Yang X, Don C, Minami E, Liu Y, Weyers J, Mahoney W, Van Biber B, Cook S, Palpant N, Gantz J, Fugate J, Muskheli V, Gough G, Vogel K, Astley C, Hotchkiss C, Baldessari A, Pabon L, Reinecke H, Gill E, Nelson V, Kiem H, Laflamme M, Murry C
    Nature, 2014;510(7504):273-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. T-cell TGF-beta signaling abrogation restricts medulloblastoma progression.
    Authors: Gate D, Danielpour M, Rodriguez J, Kim G, Levy R, Bannykh S, Breunig J, Kaech S, Flavell R, Town T
    Proc Natl Acad Sci U S A, 2014;111(33):E3458-66.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
    Authors: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J, Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
    PLoS Biol, 2014;12(8):e1001937.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. Induction of primordial germ cell-like cells from mouse embryonic stem cells by ERK signal inhibition.
    Authors: Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T
    Stem Cells, 2014;32(10):2668-78.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  39. Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells.
    Authors: Mong J, Panman L, Alekseenko Z, Kee N, Stanton L, Ericson J, Perlmann T
    Stem Cells, 2014;32(3):609-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer.
    Authors: Stengel C, Newman S, Day J, Chander S, Jourdan F, Leese M, Ferrandis E, Regis-Lydi S, Potter B, Reed M, Purohit A, Foster P
    Br J Cancer, 2014;111(2):300-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  41. Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.
    Authors: Onishi K, Tonge P, Nagy A, Zandstra P
    Stem Cell Reports, 2014;3(1):156-68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment.
    Authors: Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X
    Sci Rep, 2014;4(0):6222.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  43. Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
    Authors: Hunter, K E, Palermo, C, Kester, J C, Simpson, K, Li, J-P, Tang, L H, Klimstra, D S, Vlodavsky, I, Joyce, J A
    Oncogene, 2014;33(14):1799-808.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice.
    Authors: Tsukiyama, Tomoyuki, Ohinata, Yasuhide
    PLoS ONE, 2014;9(4):e95329.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. A novel pro-angiogenic function for interferon-gamma-secreting natural killer cells.
    Authors: Lee H, Schlereth S, Park E, Emami-Naeini P, Chauhan S, Dana R
    Invest Ophthalmol Vis Sci, 2014;55(5):2885-92.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  46. A Snail1/Notch1 signalling axis controls embryonic vascular development.
    Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
    Nat Commun, 2014;5(0):3998.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. Boundary cap neural crest stem cells homotopically implanted to the injured dorsal root transitional zone give rise to different types of neurons and glia in adult rodents.
    Authors: Trolle, Carl, Konig, Niclas, Abrahamsson, Ninnie, Vasylovska, Svitlana, Kozlova, Elena N
    BMC Neurosci, 2014;15(0):60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
    Authors: Schrode N, Saiz N, Di Talia S, Hadjantonakis A
    Dev Cell, 2014;29(4):454-67.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  49. Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2-dependent manner.
    Authors: Garcia C, Gutmann D
    PLoS ONE, 2014;9(5):e97320.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
    Authors: Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A, Taga T
    Mol Cell Biol, 2014;34(11):1976-90.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.
    Authors: Amand M, Erpicum C, Bajou K, Cerignoli F, Blacher S, Martin M, Dequiedt F, Drion P, Singh P, Zurashvili T, Vandereyken M, Musumeci L, Mustelin T, Moutschen M, Gilles C, Noel A, Rahmouni S
    Mol Cancer, 2014;13(0):108.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  52. Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
    Authors: Itoh, Yasuhiro, Moriyama, Yasunobu, Hasegawa, Tsuyoshi, Endo, Takaho A, Toyoda, Tetsuro, Gotoh, Yukiko
    Nat Neurosci, 2013;16(4):416-25.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  53. MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke.
    Authors: Liu, Xian Shu, Chopp, Michael, Wang, Xin Li, Zhang, Li, Hozeska-Solgot, Ann, Tang, Tao, Kassis, Haifa, Zhang, Rui Lan, Chen, Charles, Xu, Jennifer, Zhang, Zheng Ga
    J Biol Chem, 2013;288(18):12478-88.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. A comparative study of protocols for mouse embryonic stem cell culturing.
    Authors: Tamm C, Pijuan Galito S, Anneren C
    PLoS ONE, 2013;8(12):e81156.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  55. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
    Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
    Nat Biotechnol, 2013;31(5):426-33.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  56. Co-culture of neural crest stem cells (NCSC) and insulin producing beta-TC6 cells results in cadherin junctions and protection against cytokine-induced beta-cell death.
    Authors: Ngamjariyawat A, Turpaev K, Vasylovska S, Kozlova E, Welsh N
    PLoS ONE, 2013;8(4):e61828.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  57. Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor gamma (PPARgamma) in the conversion of white-to-brown adipocytes.
    Authors: Garcia-Alonso V, Lopez-Vicario C, Titos E, Moran-Salvador E, Gonzalez-Periz A, Rius B, Parrizas M, Werz O, Arroyo V, Claria J
    J Biol Chem, 2013;288(39):28230-42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  58. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis.
    Authors: Zhang G, Panigrahy D, Mahakian L, Yang J, Liu J, Stephen Lee K, Wettersten H, Ulu A, Hu X, Tam S, Hwang S, Ingham E, Kieran M, Weiss R, Ferrara K, Hammock B
    Proc Natl Acad Sci U S A, 2013;110(16):6530-5.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  59. A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.
    Authors: Gomez-Ospina, Natalia, Panagiotakos, Georgia, Portmann, Thomas, Pasca, Sergiu P, Rabah, Dania, Budzillo, Agata, Kinet, Jean Pie, Dolmetsch, Ricardo
    PLoS ONE, 2013;8(4):e60526.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Cell Culture Treatment
  60. Role for compartmentalization in nephron progenitor differentiation.
    Authors: Brown A, Muthukrishnan S, Guay J, Adams D, Schafer D, Fetting J, Oxburgh L
    Proc Natl Acad Sci U S A, 2013;110(12):4640-5.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  61. Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification.
    Authors: Hoffman J, Wu C, Merrill B
    Development, 2013;140(8):1665-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  62. Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system.
    Authors: Kawamoto T, Kobayashi Y, Nakajima H, Yamagishi Y
    Biochem Biophys Res Commun, 2013;441(1):180-5.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  63. Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog.
    Authors: Karwacki-Neisius V, Goke J, Osorno R, Halbritter F, Ng J, Weisse A, Wong F, Gagliardi A, Mullin N, Festuccia N, Colby D, Tomlinson S, Ng H, Chambers I
    Cell Stem Cell, 2013;12(5):531-45.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Cell Culture Substrate
  64. The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner.
    Authors: Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse S, Philippe M, Benzakour O
    Blood, 2012;120(25):5073-83.
    Species: Mouse
    Sample Type: In Vivo
    Application: Bioassay
  65. FGF23 induces left ventricular hypertrophy.
    Authors: Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutierrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-o M, Kusek JW, Keane MG, Wolf M
    J. Clin. Invest., 2011;121(11):4393-408.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  66. Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma.
    Authors: Mercapide J, Rappa G, Anzanello F
    Int. J. Cancer, 2010;126(5):1206-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  67. Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification.
    EMBO J., 2010;29(1):55-67.
    Species: Xenopus
    Sample Type: Whole Cells
    Application: Bioassay
  68. Lymphangiogenesis and angiogenesis: concurrence and/or dependence? Studies in inbred mouse strains.
    Authors: Nakao S, Maruyama K, Zandi S, Melhorn MI, Taher M, Noda K, Nusayr E, Doetschman T, Hafezi-Moghadam A
    FASEB J., 2010;24(2):504-13.
  69. Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway.
    Authors: Bai Y, Cui M, Meng Z, Shen L, He Q, Zhang X, Chen F, Xiao J
    Biochem. Biophys. Res. Commun., 2009;378(2):296-301.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  70. Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.
    Authors: Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T
    Arthritis Rheum., 2009;60(7):2019-27.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  71. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.
    Authors: Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF
    Cancer Res., 2009;69(10):4537-44.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  72. Isolation and characterization of neural stem/progenitor cells from post-stroke cerebral cortex in mice.
    Authors: Nakagomi T, Taguchi A, Fujimori Y, Saino O, Nakano-Doi A, Kubo S, Gotoh A, Soma T, Yoshikawa H, Nishizaki T, Nakagomi N, Stern DM, Matsuyama T
    Eur. J. Neurosci., 2009;29(0):1842-52.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  73. Effects of erythropoietin in skin wound healing are dose related.
    Authors: Sorg H, Krueger C, Schulz T, Menger MD, Schmitz F, Vollmar B
    FASEB J., 2009;23(9):3049-58.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth.
    Authors: Funa NS, Kriz V, Zang G, Calounova G, Akerblom B, Mares J, Larsson E, Sun Y, Betsholtz C, Welsh M
    Cancer Res., 2009;69(5):2141-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  75. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.
    Authors: Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S
    J. Biol. Chem., 2008;283(34):23139-49.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  76. Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor.
    Authors: Nyberg P, Xie L, Sugimoto H, Colorado P, Sund M, Holthaus K, Sudhakar A, Salo T, Kalluri R
    Exp. Cell Res., 2008;314(18):3292-305.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  77. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.
    Authors: Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, Ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP
    J. Neurosci., 2008;28(51):13978-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  78. Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors.
    Authors: Merchan P, Bribian A, Sanchez-Camacho C, Lezameta M, Bovolenta P, De Castro F
    Mol. Cell. Neurosci., 2007;36(3):355-68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  79. Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells.
    Authors: Gossrau G, Thiele J, Konang R, Schmandt T, Brustle O
    Stem Cells, 2007;25(4):939-49.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  80. Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells.
    Authors: Chang MY, Sun W, Ochiai W, Nakashima K, Kim SY, Park CH, Kang JS, Shim JW, Jo AY, Kang CS, Lee YS, Kim JS, Lee SH
    Mol. Cell. Biol., 2007;27(12):4293-305.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  81. Ex vivo generation of mature and functional human smooth muscle cells differentiated from skeletal myoblasts.
    Authors: Le Ricousse-Roussanne S, Larghero J, Zini JM, Barateau V, Foubert P, Uzan G, Liu X, Lacassagne MN, Ternaux B, Robert I, Benbunan M, Vilquin JT, Vauchez K, Tobelem G, Marolleau JP
    Exp. Cell Res., 2007;313(7):1337-46.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  82. ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
    Authors: Schwartz B, Shoseyov O, Melnikova VO, McCarty M, Leslie M, Roiz L, Smirnoff P, Hu GF, Lev D, Bar-Eli M
    Cancer Res., 2007;67(11):5258-66.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  83. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
    Authors: Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J
    Cell, 2007;129(5):957-68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
Expand to show all 83 Citations

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