rhOGG1 with Buffer

Catalog # Availability Size / Price Qty
4130-100-EB
Product Details
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rhOGG1 with Buffer Summary

Kit containing rhOGG1 and a buffer.

Product Description

Human 8-oxo-guanine DNA glycosylase (hOGG1) catalyzes the removal of the DNA adducts 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FaPy) through cleavage of the DNA phosphodiester bond following Schiff base chemistry. hOGG1 does not recognize the C=O of 8-oxoG as expected, but rather recognizes a proton on N7 of the nucleotide. By mispairing with adenine during replication, 8-oxoG gives rise to G:C to T:A transversions, a frequent somatic mutation in human cancers. In contrast, a FaPy lesion leads to termination of replication and, therefore, is not considered a pre-mutagenic lesion.

Kit Contents

• 10X REC™ Reaction Buffer 6
• E. coli hOGG1

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
M. Thermoautotrophicus

Limitations

For research use only. Not for diagnositic use.

Product Datasheets

Reagents Provided

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