rhOGG1 with Buffer
rhOGG1 with Buffer Summary
Human 8-oxo-guanine DNA glycosylase (hOGG1) catalyzes the removal of the DNA adducts 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FaPy) through cleavage of the DNA phosphodiester bond following Schiff base chemistry. hOGG1 does not recognize the C=O of 8-oxoG as expected, but rather recognizes a proton on N7 of the nucleotide. By mispairing with adenine during replication, 8-oxoG gives rise to G:C to T:A transversions, a frequent somatic mutation in human cancers. In contrast, a FaPy lesion leads to termination of replication and, therefore, is not considered a pre-mutagenic lesion.
• 10X REC™ Reaction Buffer 6
• E. coli hOGG1
For research use only. Not for diagnositic use.
Citations for rhOGG1 with Buffer
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Low mitochondrial DNA copy number of resected cecum appendix correlates with high severity of acute appendicitis
Authors: WC Lee, CS Lin, FC Ko, W Cheng, MH Lee, YH Wei
J. Formos. Med. Assoc., 2019;118(1):406-413. 2019
Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis.
Authors: Pfuhler S, Downs T, Allemang A, Shan Y, Crosby M
Mutagenesis, 0;32(1):5-12. 0
Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.
Authors: Cilli P, Ventura I, Minoprio A, Meccia E, Martire A, Wilson S, Bignami M, Mazzei F
Nucleic Acids Res, 0;44(11):5190-203. 0
Formation and Repair of Mismatches Containing Ribonucleotides and Oxidized Bases at Repeated DNA Sequences.
Authors: Cilli P, Minoprio A, Bossa C, Bignami M, Mazzei F
J Biol Chem, 0;290(43):26259-69. 0
Influence of oxidized purine processing on strand directionality of mismatch repair.
Authors: Repmann S, Olivera-Harris M, Jiricny J
J Biol Chem, 0;290(16):9986-99. 0
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