rhOGG1 with Buffer

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Product Details
Citations (6)
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rhOGG1 with Buffer Summary

Kit containing rhOGG1 and a buffer.

Product Description

Human 8-oxo-guanine DNA glycosylase (hOGG1) catalyzes the removal of the DNA adducts 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FaPy) through cleavage of the DNA phosphodiester bond following Schiff base chemistry. hOGG1 does not recognize the C=O of 8-oxoG as expected, but rather recognizes a proton on N7 of the nucleotide. By mispairing with adenine during replication, 8-oxoG gives rise to G:C to T:A transversions, a frequent somatic mutation in human cancers. In contrast, a FaPy lesion leads to termination of replication and, therefore, is not considered a pre-mutagenic lesion.

Kit Contents

• 10X REC™ Reaction Buffer 6
• E. coli hOGG1

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
M. Thermoautotrophicus

Limitations

For research use only. Not for diagnositic use.

Product Datasheets

Citations for rhOGG1 with Buffer

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity
    Authors: S Vodenkova, A Azqueta, A Collins, M Dusinska, I Gaivão, P Møller, A Opattova, P Vodicka, RWL Godschalk, SAS Langie
    Nat Protoc, 2020;15(12):3844-3878.  2020
  2. Low mitochondrial DNA copy number of resected cecum appendix correlates with high severity of acute appendicitis
    Authors: WC Lee, CS Lin, FC Ko, W Cheng, MH Lee, YH Wei
    J. Formos. Med. Assoc., 2019;118(1):406-413.  2019
  3. Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis.
    Authors: Pfuhler S, Downs T, Allemang A, Shan Y, Crosby M
    Mutagenesis, 0;32(1):5-12.  0
  4. Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.
    Authors: Cilli P, Ventura I, Minoprio A, Meccia E, Martire A, Wilson S, Bignami M, Mazzei F
    Nucleic Acids Res, 0;44(11):5190-203.  0
  5. Formation and Repair of Mismatches Containing Ribonucleotides and Oxidized Bases at Repeated DNA Sequences.
    Authors: Cilli P, Minoprio A, Bossa C, Bignami M, Mazzei F
    J Biol Chem, 0;290(43):26259-69.  0
  6. Influence of oxidized purine processing on strand directionality of mismatch repair.
    Authors: Repmann S, Olivera-Harris M, Jiricny J
    J Biol Chem, 0;290(16):9986-99.  0

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