rhOGG1 with Buffer
rhOGG1 with Buffer Summary
Human 8-oxo-guanine DNA glycosylase (hOGG1) catalyzes the removal of the DNA adducts 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FaPy) through cleavage of the DNA phosphodiester bond following Schiff base chemistry. hOGG1 does not recognize the C=O of 8-oxoG as expected, but rather recognizes a proton on N7 of the nucleotide. By mispairing with adenine during replication, 8-oxoG gives rise to G:C to T:A transversions, a frequent somatic mutation in human cancers. In contrast, a FaPy lesion leads to termination of replication and, therefore, is not considered a pre-mutagenic lesion.
• 10X REC™ Reaction Buffer 6
• E. coli hOGG1
- 10X REC™ Reaction Buffer 6
- E. coli hOGG1
For research use only. Not for diagnositic use.
No product specific FAQs exist for this product, however you mayView all FAQs
Reviews for rhOGG1 with Buffer
There are currently no reviews for this product. Be the first to review rhOGG1 with Buffer and earn rewards!
Have you used rhOGG1 with Buffer?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image