Catalog Number: 1271
Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Biological Activity
Potent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The heterocyclic substituted pyridine derivative (±)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.
    Bencherif et al.
    J.Pharmacol.Exp.Ther., 1998;284:886
  2. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.
    Bhatti et al.
    J.Org.Chem., 2008;73:3497
  3. Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland.
    Yokotani et al.
    Eur.J.Pharmacol., 2002;446:83
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