Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Biological Activity Potent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.
Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT
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