RJR 2429 dihydrochloride

   
Product Datasheet
Catalog Number:1271
Chemical Name:(±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Product Details
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Biological Activity
Potent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.
Technical Data
  • M.Wt:
    261.19
  • Formula:
    C12H16N2.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    1021418-53-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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