Chemical Name: (Diphenylacetyl)-carbamic acid ethy ester
Biological ActivityRo 01-6128 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat et al.
Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.
Brock et al.
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Knoflach et al.
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