Chemical Name: (Diphenylacetyl)-carbamic acid ethy ester
Biological ActivityPositive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat et al.
Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.
Brock et al.
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Knoflach et al.
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VersaClone cDNA Plasmids
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