Catalog Number: 4348
Chemical Name: (Diphenylacetyl)-carbamic acid ethy ester
Biological Activity
Positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
    Hemstapat et al.
    Mol.Pharmacol., 2006;70:616
  2. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
    Knoflach et al.
    Proc.Natl.Acad.Sci.USA, 2001;98:13402
  3. Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.
    Brock et al.
    J.Biol.Chem., 2007;282:33000
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